Estimating vaccine effectiveness against laboratory-confirmed influenza among children and adolescents in Lower Saxony and Saxony-Anhalt, 2012-2016.
Identifieur interne : 000042 ( Main/Exploration ); précédent : 000041; suivant : 000043Estimating vaccine effectiveness against laboratory-confirmed influenza among children and adolescents in Lower Saxony and Saxony-Anhalt, 2012-2016.
Auteurs : A. Möhl [Allemagne] ; L. Gr Fe [Allemagne] ; C. Helmeke [Allemagne] ; D. Ziehm [Allemagne] ; M. Monazahian [Allemagne] ; H-M Irmscher [Allemagne] ; J. Dreesman [Allemagne]Source :
- Epidemiology and infection [ 1469-4409 ] ; 2018.
Descripteurs français
- KwdFr :
- Adolescent, Allemagne, Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine (), Humains, Modèles logistiques, Mâle, Nourrisson, Saisons, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (immunologie), Surveillance sentinelle, Vaccins antigrippaux (immunologie), Vaccins antigrippaux (usage thérapeutique), Virus influenza B (immunologie).
- MESH :
- immunologie : Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Vaccins antigrippaux, Virus influenza B.
- usage thérapeutique : Vaccins antigrippaux.
- Adolescent, Allemagne, Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine, Humains, Modèles logistiques, Mâle, Nourrisson, Saisons, Surveillance sentinelle.
English descriptors
- KwdEn :
- Adolescent, Child, Child, Preschool, Female, Germany, Humans, Infant, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza B virus (immunology), Influenza Vaccines (immunology), Influenza Vaccines (therapeutic use), Influenza, Human (prevention & control), Logistic Models, Male, Seasons, Sentinel Surveillance.
- MESH :
- chemical , immunology : Influenza Vaccines.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza B virus.
- prevention & control : Influenza, Human.
- chemical , therapeutic use : Influenza Vaccines.
- Adolescent, Child, Child, Preschool, Female, Germany, Humans, Infant, Logistic Models, Male, Seasons, Sentinel Surveillance.
Abstract
Influenza vaccine effectiveness (VE) has to be estimated anew for every season to explore vaccines' protective effect in the population. We report VE estimates against laboratory-confirmed influenza A(H1N1)pdm09, A(H3N2) and influenza B among children aged 2-17 years, using test-negative design. Pooled data from two German federal states' surveillance systems for acute respiratory illness from week 40/2012 to 20/2016 was used, yielding a total of 10 627 specimens. Odds ratios and 95% confidence intervals (95% CIs) for the association between laboratory-confirmed influenza and vaccination status were calculated by multivariate logistic regression adjusting for age, sex, illness onset and federal state. VE was estimated as 1-Odds Ratio. Overall adjusted VE was 33% (95% CI: 24·3-40·7). A strong variation of VE between the seasons and subtypes was observed: highest season- and subtype-specific VE of 86·2% (95% CI: 41·3-96·7) was found against A(H1N1)pdm09 in 7-17-year-olds in 2015/16. Low estimates of VE were observed against A(H3N2) in any season, e.g. 1·5% (95% CI: -39·3-30·3) in 2014/15. Estimates showed a tendency to higher VE among 7-17-year-old children, but differences were not statistically significant. Although our findings are common in studies estimating influenza VE, we discussed several explanations for observed low VE.
DOI: 10.1017/S0950268817002709
PubMed: 29208075
Affiliations:
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Möhl</name><affiliation wicri:level="1"><nlm:affiliation>Governmental Institute of Public Health of Lower Saxony,Hannover,Lower Saxony,Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Governmental Institute of Public Health of Lower Saxony,Hannover,Lower Saxony</wicri:regionArea><wicri:noRegion>Lower Saxony</wicri:noRegion><wicri:noRegion>Lower Saxony</wicri:noRegion><wicri:noRegion>Lower Saxony</wicri:noRegion></affiliation></author><author><name sortKey="Gr Fe, L" sort="Gr Fe, L" uniqKey="Gr Fe L" first="L" last="Gr Fe">L. Gr Fe</name><affiliation wicri:level="1"><nlm:affiliation>State Agency for Consumer Protection of Saxony-Anhalt,Magdeburg,Saxony-Anhalt,Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>State Agency for Consumer Protection of Saxony-Anhalt,Magdeburg,Saxony-Anhalt</wicri:regionArea><wicri:noRegion>Saxony-Anhalt</wicri:noRegion><wicri:noRegion>Saxony-Anhalt</wicri:noRegion><wicri:noRegion>Saxony-Anhalt</wicri:noRegion></affiliation></author><author><name sortKey="Helmeke, C" sort="Helmeke, C" uniqKey="Helmeke C" first="C" last="Helmeke">C. 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Ziehm</name><affiliation wicri:level="1"><nlm:affiliation>Governmental Institute of Public Health of Lower Saxony,Hannover,Lower Saxony,Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Governmental Institute of Public Health of Lower Saxony,Hannover,Lower Saxony</wicri:regionArea><wicri:noRegion>Lower Saxony</wicri:noRegion><wicri:noRegion>Lower Saxony</wicri:noRegion><wicri:noRegion>Lower Saxony</wicri:noRegion></affiliation></author><author><name sortKey="Monazahian, M" sort="Monazahian, M" uniqKey="Monazahian M" first="M" last="Monazahian">M. Monazahian</name><affiliation wicri:level="1"><nlm:affiliation>Governmental Institute of Public Health of Lower Saxony,Hannover,Lower Saxony,Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Governmental Institute of Public Health of Lower Saxony,Hannover,Lower Saxony</wicri:regionArea><wicri:noRegion>Lower Saxony</wicri:noRegion><wicri:noRegion>Lower Saxony</wicri:noRegion><wicri:noRegion>Lower Saxony</wicri:noRegion></affiliation></author><author><name sortKey="Irmscher, H M" sort="Irmscher, H M" uniqKey="Irmscher H" first="H-M" last="Irmscher">H-M Irmscher</name><affiliation wicri:level="1"><nlm:affiliation>State Agency for Consumer Protection of Saxony-Anhalt,Magdeburg,Saxony-Anhalt,Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>State Agency for Consumer Protection of Saxony-Anhalt,Magdeburg,Saxony-Anhalt</wicri:regionArea><wicri:noRegion>Saxony-Anhalt</wicri:noRegion><wicri:noRegion>Saxony-Anhalt</wicri:noRegion><wicri:noRegion>Saxony-Anhalt</wicri:noRegion></affiliation></author><author><name sortKey="Dreesman, J" sort="Dreesman, J" uniqKey="Dreesman J" first="J" last="Dreesman">J. Dreesman</name><affiliation wicri:level="1"><nlm:affiliation>Governmental Institute of Public Health of Lower Saxony,Hannover,Lower Saxony,Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Governmental Institute of Public Health of Lower Saxony,Hannover,Lower Saxony</wicri:regionArea><wicri:noRegion>Lower Saxony</wicri:noRegion><wicri:noRegion>Lower Saxony</wicri:noRegion><wicri:noRegion>Lower Saxony</wicri:noRegion></affiliation></author></analytic><series><title level="j">Epidemiology and infection</title><idno type="eISSN">1469-4409</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Germany</term><term>Humans</term><term>Infant</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H3N2 Subtype (immunology)</term><term>Influenza B virus (immunology)</term><term>Influenza Vaccines (immunology)</term><term>Influenza Vaccines (therapeutic use)</term><term>Influenza, Human (prevention & control)</term><term>Logistic Models</term><term>Male</term><term>Seasons</term><term>Sentinel Surveillance</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Allemagne</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Grippe humaine ()</term><term>Humains</term><term>Modèles logistiques</term><term>Mâle</term><term>Nourrisson</term><term>Saisons</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H3N2 du virus de la grippe A (immunologie)</term><term>Surveillance sentinelle</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins antigrippaux (usage thérapeutique)</term><term>Virus influenza B (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Virus influenza B</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza B virus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Germany</term><term>Humans</term><term>Infant</term><term>Logistic Models</term><term>Male</term><term>Seasons</term><term>Sentinel Surveillance</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Allemagne</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Modèles logistiques</term><term>Mâle</term><term>Nourrisson</term><term>Saisons</term><term>Surveillance sentinelle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza vaccine effectiveness (VE) has to be estimated anew for every season to explore vaccines' protective effect in the population. We report VE estimates against laboratory-confirmed influenza A(H1N1)pdm09, A(H3N2) and influenza B among children aged 2-17 years, using test-negative design. Pooled data from two German federal states' surveillance systems for acute respiratory illness from week 40/2012 to 20/2016 was used, yielding a total of 10 627 specimens. Odds ratios and 95% confidence intervals (95% CIs) for the association between laboratory-confirmed influenza and vaccination status were calculated by multivariate logistic regression adjusting for age, sex, illness onset and federal state. VE was estimated as 1-Odds Ratio. Overall adjusted VE was 33% (95% CI: 24·3-40·7). A strong variation of VE between the seasons and subtypes was observed: highest season- and subtype-specific VE of 86·2% (95% CI: 41·3-96·7) was found against A(H1N1)pdm09 in 7-17-year-olds in 2015/16. Low estimates of VE were observed against A(H3N2) in any season, e.g. 1·5% (95% CI: -39·3-30·3) in 2014/15. Estimates showed a tendency to higher VE among 7-17-year-old children, but differences were not statistically significant. Although our findings are common in studies estimating influenza VE, we discussed several explanations for observed low VE.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29208075</PMID><DateCompleted><Year>2018</Year><Month>09</Month><Day>21</Day></DateCompleted><DateRevised><Year>2018</Year><Month>09</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-4409</ISSN><JournalIssue CitedMedium="Internet"><Volume>146</Volume><Issue>1</Issue><PubDate><Year>2018</Year><Month>01</Month></PubDate></JournalIssue><Title>Epidemiology and infection</Title><ISOAbbreviation>Epidemiol. Infect.</ISOAbbreviation></Journal><ArticleTitle>Estimating vaccine effectiveness against laboratory-confirmed influenza among children and adolescents in Lower Saxony and Saxony-Anhalt, 2012-2016.</ArticleTitle><Pagination><MedlinePgn>78-88</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1017/S0950268817002709</ELocationID><Abstract><AbstractText>Influenza vaccine effectiveness (VE) has to be estimated anew for every season to explore vaccines' protective effect in the population. We report VE estimates against laboratory-confirmed influenza A(H1N1)pdm09, A(H3N2) and influenza B among children aged 2-17 years, using test-negative design. Pooled data from two German federal states' surveillance systems for acute respiratory illness from week 40/2012 to 20/2016 was used, yielding a total of 10 627 specimens. Odds ratios and 95% confidence intervals (95% CIs) for the association between laboratory-confirmed influenza and vaccination status were calculated by multivariate logistic regression adjusting for age, sex, illness onset and federal state. VE was estimated as 1-Odds Ratio. Overall adjusted VE was 33% (95% CI: 24·3-40·7). A strong variation of VE between the seasons and subtypes was observed: highest season- and subtype-specific VE of 86·2% (95% CI: 41·3-96·7) was found against A(H1N1)pdm09 in 7-17-year-olds in 2015/16. Low estimates of VE were observed against A(H3N2) in any season, e.g. 1·5% (95% CI: -39·3-30·3) in 2014/15. Estimates showed a tendency to higher VE among 7-17-year-old children, but differences were not statistically significant. Although our findings are common in studies estimating influenza VE, we discussed several explanations for observed low VE.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Möhl</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Governmental Institute of Public Health of Lower Saxony,Hannover,Lower Saxony,Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gräfe</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>State Agency for Consumer Protection of Saxony-Anhalt,Magdeburg,Saxony-Anhalt,Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Helmeke</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>State Agency for Consumer Protection of Saxony-Anhalt,Magdeburg,Saxony-Anhalt,Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ziehm</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Governmental Institute of Public Health of Lower Saxony,Hannover,Lower Saxony,Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monazahian</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Governmental Institute of Public Health of Lower Saxony,Hannover,Lower Saxony,Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Irmscher</LastName><ForeName>H-M</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>State Agency for Consumer Protection of Saxony-Anhalt,Magdeburg,Saxony-Anhalt,Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dreesman</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Governmental Institute of Public Health of Lower Saxony,Hannover,Lower Saxony,Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>12</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Epidemiol Infect</MedlineTA><NlmUniqueID>8703737</NlmUniqueID><ISSNLinking>0950-2688</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N">Germany</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009981" MajorTopicYN="N">Influenza B virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018571" MajorTopicYN="N">Sentinel Surveillance</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Epidemiology</Keyword><Keyword MajorTopicYN="Y">influenza (seasonal)</Keyword><Keyword MajorTopicYN="Y">routine surveillance data</Keyword><Keyword MajorTopicYN="Y">test-negative design</Keyword><Keyword MajorTopicYN="Y">vaccine effectiveness</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>12</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>12</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29208075</ArticleId><ArticleId IdType="pii">S0950268817002709</ArticleId><ArticleId IdType="doi">10.1017/S0950268817002709</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Mohl, A" sort="Mohl, A" uniqKey="Mohl A" first="A" last="Möhl">A. Möhl</name></noRegion><name sortKey="Dreesman, J" sort="Dreesman, J" uniqKey="Dreesman J" first="J" last="Dreesman">J. Dreesman</name><name sortKey="Gr Fe, L" sort="Gr Fe, L" uniqKey="Gr Fe L" first="L" last="Gr Fe">L. Gr Fe</name><name sortKey="Helmeke, C" sort="Helmeke, C" uniqKey="Helmeke C" first="C" last="Helmeke">C. Helmeke</name><name sortKey="Irmscher, H M" sort="Irmscher, H M" uniqKey="Irmscher H" first="H-M" last="Irmscher">H-M Irmscher</name><name sortKey="Monazahian, M" sort="Monazahian, M" uniqKey="Monazahian M" first="M" last="Monazahian">M. Monazahian</name><name sortKey="Ziehm, D" sort="Ziehm, D" uniqKey="Ziehm D" first="D" last="Ziehm">D. Ziehm</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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